In another meta-analysis, sciatic nerve block in combination with femoral nerve block was reported to significantly reduce postoperative opioid consumption and knee pain following TKA compared with femoral nerve block alone. Considering all aspects, the combination of femoral and sciatic nerve block was considered the gold-standard PNB for patients undergoing TKA in this meta-analysis. In addition, the five most effective combinations for reduction of opioid consumption are the femoral/sciatic/obturator, femoral/obturator, lumbar plexus/sciatic, lumbar plexus, and femoral/sciatic blocks. In a recent network meta-analysis, which ranked the efficacy of 17 available analgesic modalities, five combinations that were most effective for pain at rest included femoral/obturator, femoral/ sciatic/obturator, lumbar plexus/sciatic, femoral/sciatic, and fascia iliaca compartment blocks. PNBs for TKA have been reported to be associated with decreased length of hospital stay and a significant reduction in the risk for readmission. PNBs not only reduce pain but also have a positive effect on resource use after TKA. SPECIFIC PERIPHERAL NERVE BLOCKS SPECIFIC PERIPHERAL NERVE BLOCKS Intra-articular innervations of the menisci, perimeniscular joint capsule, cruciate ligaments, infrapatellar fat pad, and posterior part of the fibrous knee capsule are supplied by the tibial nerve and posterior branch of the obturator nerve. A medial parapatellar arthrotomy, through the anteromedial aspect of the skin, subcutaneous tissue, deep fascia, retinacular ligaments, and fibrous capsule, will evoke pain mediated mainly by the infrapatellar branch of the saphenous nerve, the terminal branch of the nerve to the vastus medialis muscle, and the anterior branch of the medial femoral cutaneous nerve. The most common approach to TKA is the medial parapatellar arthrotomy, which involves a longitudinal midline incision through the skin and subcutaneous tissue extending from 5 cm proximal to the superior pole of the patella to the tibial tuberosity. Branches of the femoral nerve to the knee are primarily the saphenous nerve, intermediate and medial femoral cutaneous nerves and, additionally, nerves to the vastus lateralis, intermedius, and medialis muscles. The knee joint is primarily innervated by the femoral, obturator, and sciatic nerves. NERVOUS INNERVATION OF THE KNEE NERVOUS INNERVATION OF THE KNEE The purpose of this review is to describe optimal analgesic blocks, as a part of multimodal analgesia used for TKA, and the scientific basis of each block. Given the prospect of improved postoperative pain control and reduced opioid consumption, multimodal analgesia, including PNBs, appears to be promising in older adults undergoing TKA. The ideal pain management modality should provide excellent analgesia while minimizing opioid consumption and enhancing rehabilitation. There are multiple strategies to control postoperative pain after TKA, including administration of systemic or intrathecal opioids, local infiltration of analgesia, and peripheral nerve blocks (PNBs). TKA, however, is a painful procedure, and inadequate postoperative analgesia hinders rehabilitation, prolongs hospitalization, and is associated with an increased risk for adverse events including myocardial ischemia, pulmonary dysfunction, and thromboembolism. Total knee arthroplasty (TKA) is a common surgical procedure for treating patients experiencing chronic pain associated with advanced osteoarthritis.
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